C2383-02B-ML650
CD31 (PECAM-1, Platelet gpIIa Molecule) (MaxLight 650)
Size
£756.00
- SKU:
- C2383-02B-ML650
- Purity:
- Purified by Protein A affinity chromatography.
- Storage Conditions:
- 4°C Do Not Freeze
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Leukocytes from LGL-type leukemia patient
- Clone:
- 6A24 (MEM-05)
- Format:
- Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with MaxLight™650.
- Extra Details:
- MaxLight™ 650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. CD31 (PECAM-1, or platelet/endothelial cell adhesion molecule 1) is a 130kD glycoprotein expressed on the surface of endothelial cells, platelets, and several leukocyte subsets. CD31 is localized at places of cell-cell contact, and has sequence homology to CEA (carcinoembryonic antigen) which is a known intracellular adhesion molecule (ICAM). CD31 is involved in endothelial cell tube formation, is believed to promote cell-cell adhesion during the assembly of vascular structures, and may also regulate macrophage recognition and inflammatory and immune responses. CD31 is able to bind itself, as well as to integrin alphaV beta3, which is an integrin involved in endothelial cell matrix adhesion. Other reported ligands for CD31 include glycosaminoglycans and CD38. CD31 is involved in the regulatory T cell activation, and plays a role in the diapedesis step of leukocyte emigration during inflammation. Applications: Suitable for use in Western Blot, Flow Cytometry and Immunohistochemistry. Other applications have not been tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice