C2276-10
CD25 (Tac antigen, p55, Interleukin 2 Receptor alpha, IL2Ra, T Cell Growth Factor Receptor)
Size
£812.00
- SKU:
- C2276-10
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant protein corresponding to human interleukin 2 receptor. Cellular Localization: Cell membrane
- Clone:
- 0.N.93 (IL2R.1)
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See C2276-10X.
- Extra Details:
- CD25, otherwise known as the Tac antigen or p55, is the alpha chain of the Interleukin-2 (IL-2) receptor. The IL-2 receptor is expressed on activated cells including T cells, B cells and monocytes. It is also present on a subset of thymocytes, HTLV-1 transformed T and B cells, EBV transformed B cells, myeloid precursors and oligodendrocytes. IL-2 induces the expression of the CD25 subunit on NK cells. The IL-2 receptor consists of at least three distinct membrane components: the alpha chain (IL-2R-alpa, Tac, CD25), the beta chain (IL-2R-beta, p75, CD122), and the gamma chain (IL-2R-gamma). CD25 is undetectable on resting T cells but is induced upon T-cell activation. Applications: Suitable for use in Flow Cytometry and Immunofluorescence. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: Tonsil or lymph node Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice