C2262-51Q
CD11b (Integrin alpha-M, CD11 Antigen-like family Member B, CR-3 alpha Chain, Cell Surface Glycoprotein MAC-1 Subunit alpha, Leukocyte Adhesion Receptor MO1, Neutrophil Adherence Receptor, ITGAM, CR3A)
Size
£320.00
- SKU:
- C2262-51Q
- Purity:
- Purified by affinity chromatography
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Clone:
- ICRF44
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
- Extra Details:
- CD11b is a 165-170kD type I transmembrane glycoprotein also known as aM integrin, Mac-1, CR3, and C3biR. CD11b non-covalently associates with integrin B2 (CD18) and is expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b/CD18 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis and neutrophil activation. CD11b/CD18 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen and Factor X. This antibody inhibits heterotypic adhesion of granulocytes in response to fMLP. Applications: Suitable for use in Immunofluorescence, Flow Cytometry, Blocking of Granulocyte Activation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: ≤0.5ug/10e6 cells in 100ul volume or 100ul of whole blood Immunohistochemistry: Acetone-fixed, frozen tissue sections Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice