C2262-29A

CD11a (Leukocyte Function Associated Antigen, LFA-1, Integrin aL)

Size

£288.00

SKU:: C2262-29A
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Fibronectin purified monocytes
Clone:: 38
Format:: Supplied as a liquid in 100mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.
Extra Details:: CD11a, also known as leukocyte function-associated antigen-1 (LFA-1alpha), represents the 180kD integrin alphaL subunit which combines with the CD18 beta2 integrin subunit to form the alphaLbeta2 integrin heterodimer. It is expressed on lymphocytes, granulocytes, monocytes, and macrophages and is upregulated on activated T cells. CD11a/LFA-1alpha mediates adhesion of lymphocytes to vascular endothelium and is involved in costimulation.1-5 Applications: • Flow cytometry • Studies in cell adhesion and cytotoxicity • Immunohistochemisty (frozen sections) • Immunoprecipitation • Blocking studies Recommended Dilution: Flow Cytometry: ≤ 1ug/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.