C2100P
CCR8, Blocking Peptide (TER1, CKR-L1, ChemR1, Chemokine Receptor 8, CC-CKR-8)
Size
£369.00
- SKU:
- C2100P
- Purity:
- Purified
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.
- Extra Details:
- Peptide corresponding to amino acids 183 to 201 of human CCR8, which locate in the second extracellular loop (1-3). CCR8 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human and murine CCR8 were cloned and designated TER1, CKR-L1, and ChemR1 (1-4). The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage-tropic HIV-1 strains (5). CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection, which can be prevented by the CCR8 ligand I-309. CCR8 is expressed in spleen, thymus and T lymphoblastic cell lines. Applications: Suitable for use in blocking the activity of anti-CCR8 (Catalog #C2100). Recommended Dilution: Blocking: Incubating the pepetide with equal volume of antibody for 30 minutes at 37°C usuallly completely blocks the antibody activity in Western Blot. Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
- Shipping Conditions:
- Blue Ice