CCR3 (C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil Eotaxin Receptor, CD193)

Size

£576.00

SKU:: C2099-67B
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: C-VETFGTTSYYDDVGLLCEKADTRALMA 28 amino acid synthetized corresponding to aa 8-34 (cysteine added for coupling) of the N-terminal domain of human CCR3
Format:: Supplied as a liquid in PBS, pH 7.2, 1mg/ml BSA, 0.09% sodium azide.
Extra Details:: CCR3 has been reported in blood, brain, lung, bone marrow, kidney, liver, lymph node, placenta, skin, spleen, thymus, thyroid, uterus and vessel. Within these tissues, CCR3 is expressed in specific cell types, including eosinophils, basophils, Th2 cells, and mast cells. The agonists for CXCR3 (IP-10, mig, and I-TAC) act as antagonists for CCR3 by competing for the binding of eotaxin to CCR3. The CCR3 receptor is expressed on human eosinophils, basophils, neutrophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitor cells, Th2-like lymphocytes and keratinocytes. CCR3 is thought to play a key role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and -2 and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types. The CCR3 receptor has been reported to be upregulated by high affinity Fc IgE receptor ligation. Human CCR3 is a receptor for CC chemokine eotaxin-1 and eotaxin-2. CCR 3 is constitutively expressed on eosinophils, small intestine and colon. The human CCR3 protein contains 356 amino acids. Applications: Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:30,000 Western Blot: 1:500 Immunohistochemistry: 1:150 Optimal dilutions to be determined by the researcher. Positive Control: Human peripheral blood cells. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice