Caveolin 1 (CAV1, caveolae protein, 22kD , HGNC:1527, CAV, MSTP085, VIP21, caveolin 1, alpha isoform, caveolin 1, beta isoform, cell growth-inhibiting protein 32)

Size

£642.00

SKU:: C2097-91E
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Goat
Immunogen:: Synthetic peptide (C-DELSEKQVYDAH) from the internal region of human caveolin 1.
Format:: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Extra Details:: Cav1 is a 21kD scaffolding protein which is the main component of the caveolae plasma membranes found in most cell types. Two isoforms (alpha and beta) are encoded by a single transcript from this gene. Cav1 is highly expressed in terminally differentiated or quiescent cells, suggesting a possible role for Cav1 as a negative regulator of cell proliferation. Cav1 has been implicated in the pathogenesis of oncogenic cell transformation, tumorigenesis, and metastasis and functions as a “tumor and/or metastasis-modifying gene”. For example Cav1 normally functions as a negative regulator of cell transformation and mammary tumorigenesis, whilst in prostate cancers Cav1 may function as a tumor promoter. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.3-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice