CaV3.1 (Calcium Channel CaV3.1, CACNA1G)

Size

£709.00

SKU:: C2097-86
Application:: WB
Purity:: Purified by affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to aa1-22, MDEEEDGAGAEESGQPRSFTQL(C) from rat CaV3.1. Species sequence homology: Human-20/22.
Format:: Supplied as a lyophilized powder in PBS, pH 7.4, 1% BSA, 5% sucrose, 0.05% sodium azide. Reconstitute with sterile ddH2O.
Extra Details:: Calcium channel, voltage-dependent, T type, α 1G subunit is a protein encoded by CACNA1G gene in humans. It belongs to a family of voltage-gated calcium channels and serves as the key transducer of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events. CACNA1G (T-type channels) are involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance and rebound burst firing. It exhibits a significant window current that helps for Fe2+ pathway entry into cells with relevant concentrations of extracellular Fe2+. The window current also creates a pathway for Cd2+ entry into cells during Cd2+ exposure. CACNA1G were found to be associated with Autism Spectrum Disorder. Applications: Suitable for use in Western Blot. Other applications have not been tested. Recommended Dilution: Western Blot: 1:200 using ECL on rat brain membranes Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice