Capsaicin Receptor

Size

£735.00

SKU:: C1078-06
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to amino acids 7-21, TDLGAAADPLQKDTC of human Vanilloid Receptor 1.
Format:: Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
Extra Details:: Vanilloid Receptor 1 (VR1), also known as capsaicin receptor, responds to both capsaicin, the pungent ingredient in hot peppers, and thermal stimuli within the noxious temperature range. This receptor is structurally related to the TRP family of ion channels and is predicted to contain 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. VR1 is highly permeable to divalent cations, including calcium and magnesium, as well as the monovalent cations sodium and potassium. Expression of VR1 appears to be limited to neurons within the sensory ganglia. Applications: Suitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Frozen): 1ug/ml. Staining of VR1 in human glabrous skin results in the staining of epidermal and dermal cells, as well as free nerve fibers and Merkel cells. Immunofluorescence: 1ug/ml. Staining of VR1 in human prostatic urethra results in fibrous staining within epithelial cells. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice