C1075-25

Canertinib, Dihydrochloride (N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide Dihydrochloride, CI-1033, PD183805)

Size

£190.00

SKU:: C1075-25
Molecular Weight:: 558.86
Purity:: ~99% HPLC, TLC
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 289499-45-2
Format:: Supplied as an off-white to pale green powder.
Extra Details:: Canertinib (CI-1033, PD 183805) is a pan-erbB tyrosine kinase inhibitor. It selectively inhibits erbB1 (epidermal growth factor receptor), erbB2, erbB3, and erbB4 without blocking tyrosine kinase activity of many other receptors such as platelet-derived growth factor receptor, fibroblast growth factor receptor, and insulin receptor. Solubility: Soluble in DMSO at 100mg/ml; soluble in ethanol at 1mg/ml with warming; soluble in water at 10mg/ml with warming; buffers, serum, or other additives may increase or decrease the aqueous solubility. Compound is somewhat unstable in HPLC sample solution at room temperature. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.