C0108-35A

Cadherin N, Control Peptide (Cadherin 2, Neuronal, CDH2)

Size

£512.00

SKU:: C0108-35A
Application:: WB
Purity:: 95+% HPLC, Mass Spec
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a white to off-white lyophilized powder.
Extra Details:: Cadherins are a family of CA2+ dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenin (alpha, beta and gamma). Members of the cadherin family include Cadherin 6 (K-Cadherin), P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-Cadherin, cadherin 5, L-CAM and EP-Cadherin. N-Cadherin mRNA is found at elevated levels in brain and heart and at much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation and protease mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogeneous kinases and phosphatases. Tyrosine phosphorylation of Beta-Catenin complexed with N-Cadherin results in dissociation of N-Cadherin from actin. However, N-Cadherin also interacts with a PTP1-B-like phosphatase that dephosphorylates B-catenin and promotes N-Cadherin/actin association. This, N-Cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events. Applications: Suitable for use in Western Blotting. Other applications not tested. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice