C0107-05A
Cadherin 6 (K-Cadherin, Fetal Kidney, CDH6)
Size
£871.00
- SKU:
- C0107-05A
- Application:
- IHC-Fr
- Purity:
- Supernatant
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- GST fusion protein corresponding to part of the extracellular domain of Cadherin 6
- Clone:
- 5F95
- Format:
- Supplied as a liquid, 0.09% sodium azide.
- Extra Details:
- The cadherin gene family encodes calcium-dependent adhesion molecules that promote homophilic interactions among cells. All cadherins are single-pass transmembrane proteins with a variable number of extracellular domains (EC; 110 amino acids long). Classical cadherins consist of five EC domains and a conserved cytoplasmic domain and are divided in type I and type II subgroups. Type I comprises cadherin E, N, P, and R. Type II include cadherin-5, -6, -8, -11, and -12. During embryogenesis differential expression of cadherins can drive morphogenesis by stimulating cell aggregation, defining boundaries between groups of cells and promoting cell migration. Cadherin-6 seems to be required for the early aggregation of induced mesenchymal cells and their subsequent conversion to epithlium. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Frozen): Paraformaldehyde fixed, with 0.2% Triton X-100 in PBS. Incubate for 1 hr at RT or overnight at 4°C. Optimal dilutions to be determined by the researcher. Positive Control: Embryonic kidney (e.g. establishment of developmental pattern of nephrons). Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice