C0050-012

Carcinoembryonic Antigen (CEA)

Size

£678.00

SKU:: C0050-012
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Human carcinoembryonic antigen (CEA).
Clone:: CEA-Y2
Format:: Supplied as a lyophilized powder from 0.01M PBS, pH7.2. Reconstitute with 500ul sterile dH2O.
Extra Details:: Human carcinoembryonic antigen (CEA) belongs to a family of membrane glycoproteins that are overexpressed in many carcinomas. It functions in vitro as a homotypic intercellular adhesion molecule and can inhibit differentiation when expressed ectopically in myoblasts. It was originally described as a glycoprotein molecule with an oncofetal expression pattern. It is a member of a family of closely related molecules, whose genes reveal a high degree of sequence similarity. The CEA family shows structural resemblance to, and can be placed within, the immunoglobulin superfamily. CEA may function as a cell adhesion molecule, which could play an important role during embryogenesis and possibly also during tumor development. Despite its presence in some normal tissues, its concentration in serum is a clinically useful parameter, especially in the postoperative monitoring of colonic tumor patients. It maps to 19q13.1-q13.2 region of human chromosome. It is found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice