C0026-11K
c-erbB2 (HER-2, Neu Receptor)
Size
£978.00
- SKU:
- C0026-11K
- Purity:
- Purified by Protein G affinity chromatography from ascites.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Intact SKBR-3 breast cancer cells. Cellular Localization: Cell membrane. Epitope: Extracellular domain.
- Clone:
- 3F30
- Format:
- Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
- Extra Details:
- c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein. Applications: Suitable for use in Tumor Growth Inhibition, Inhibition of Cell Proliferation, Electron Microscopy, Immunofluorescence, and Immunohistochemistry. Not suitable for use in Immunoprecipitation. Other applications have not been tested. Recommended Dilution: Tumor Growth Inhibition (~90%) Immunohistochemistry: Frozen only. Optimal dilutions to be determined by the researcher. Positive Control: SKBR-3 cells, or breast carcinomas Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice