C0010-02E
Complement C1q (Complement Component 1, q Subcomponent)
Size
£825.00
- SKU:
- C0010-02E
- Purity:
- Purified by Protein A affinity chromatography from ascites.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Globular head domain of Complement C1q, purified from human plasma.
- Clone:
- 3R9/2
- Format:
- Supplied as a liquid in borate buffered saline, 0.09% sodium azide.
- Extra Details:
- Human complement component 1, q subcomponent (C1q) is a 156kD secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis. Applications: Suitable for use in ELISA, Flow Cytometry, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry (Frozen): 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Kidney tissue from patients with streptococcal glomerulonephritis. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice