C0005-75A

ABRA1 (Abraxas 1, CCDC98, FAM175A)

Size

£544.00

SKU:: C0005-75A
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag
Clone:: ABRA1-01
Format:: Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Extra Details:: ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation. Applications: Suitable for use in Flow Cytometry, Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: reducing conditions Flow Cytometry: 1-2ug/ml. Intracellular staining. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.