B0807-12V
Bcl10 (B Cell CLL/lymphoma 10, B Cell lymphoma/leukemia 10, CARD-containing Molecule Enhancing NF-kappa-B, CARD-like apoptotic protein, CARMEN, cCARMEN, c-E10, CED-3/ICH-1 prodomain homologous E10-like regulator, Cellular-E10, Cellular homolog of vCARMEN, CIPER, CLAP, hCLAP, Mammalian CARD-containing adapter molecule E10, mE10)
Size
£588.00
- SKU:
- B0807-12V
- Purity:
- Ascites
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Purified recombinant fragment of human BCL-10 expressed in E. coli.
- Clone:
- 4F8E8H8,4F8E3H8
- Format:
- Supplied as a liquid, 0.03% sodium azide.
- Extra Details:
- Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:200-1:400 ELISA: 1:10,000 Western Blot: 1:500-1:2000 Immunohistochemistry(Paraffin): 1:200-1:1000 Immunocytochemistry: 1:200-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice