B0807-02F1

Bcl 2, Recombinant, Human, aa1-211, His-Tag (B Cell lymphoma protein 2 alpha, Apoptosis regulator Bcl-2, Bcl-2)

Size

£1,035.00

SKU:: B0807-02F1
Molecular Weight:: 27
Purity:: Purified (~90%)
Storage Conditions:: -70°C
Supplier:: United States Biological
Format:: Supplied as a liquid in 25mM Tris-HCl, pH 8.0, 100mM sodium chloride, 0.05% Tween 20, 3mM DTT, 30% glycerol.
Extra Details:: Bcl-2, also known as B-cell lymphoma protein 2 alpha, is an anti-apoptotic protein located primarily in the outer mitochondrial membrane that blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apotosis. Bcl-2 exerts its anti-apoptotic function through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). The Bcl-2 gene has been related with a number of cancers, including melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity. Source: Recombinant protein corresponding to human Bcl2, aa1-211, with C-terminal His-Tag, expressed in E. coli. Molecular Weight: ~27kD Applications: Suitable for use in the study of apoptosis, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.

Shipping Conditions:: Dry Ice