B0003-69
BAFF (TNFSF13B, BlyS, THANK, TALL 1)
Size
£594.00
- SKU:
- B0003-69
- Application:
- WB
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- C-terminal peptide corresponding to aa 254-269 of human BLyS.
- Format:
- Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
- Extra Details:
- Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 (1), THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase (2), BAFF (for B cell activating factor belonging to the TNF family) (3) and Blys (B lymphocyte stimulator) (4). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted Blys/BAFF/THANK acts as a potent B cell growth factor. This protein is expressed abundantly in peripheral blood lymphocytes, specifically in monocytes and macrophages. Its regulation is upregulated by interferon gamma. Overexpression of Blys/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune –like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc. (5) Recently, two receptors for Blys/BAFF have been identified and termed as BCMA and TACI (6). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice