B0003-64P
BAFF (B cell Activating Factor belonging to TNF Family, BLyS, TALL-1, THANK)
Size
£832.00
- SKU:
- B0003-64P
- Purity:
- Purified from ascites.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rat
- Immunogen:
- Rat RBL cells expressing mouse BAFF.
- Clone:
- 6D145 (5A8)
- Format:
- Supplied as a liquid in PBS, 0.02% sodium azide.
- Extra Details:
- Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-£eB and c-jun N-terminal kinase. Applications: Suitable for use in ELISA, Flow Cytometry and Western Blot. Other applications have not been tested. Recommended Dilutions: ELISA: Capture Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice