A2298-59D
AP-2 alpha
Size
£581.00
- SKU:
- A2298-59D
- Application:
- WB
- Purity:
- Purified by Protein A and peptide affinity chromatography
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to a sequence of human AP-2 alpha.
- Format:
- Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
- Extra Details:
- The sequence-specific transcription factor activator protein 2 alpha (AP-2 alpha) is required for normal growth and morphogenesis during mammalian development (1,2). Decreased or loss of AP-2 alpha expression has been observed in many different types of human cancers including breast cancer (3,4), ovarian cancer (5), melanoma (6) and prostate cancer (7). These findings suggest that AP-2alpha expression plays a crucial role in tumorigenicity. Studies have also shown that p53 overexpression in human breast carcinoma cells induces the level of AP-2 alpha expression. Furthermore, p53 binds to the cis-element in the AP-2alpha promoter, suggesting that AP-2 alpha is a target of p53. AP-2 alpha may mediate the effect of p53 to inhibit cell proliferation (8). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice