A2275-78A-ML650
β-Amyloid (MaxLight 650)
Size
£960.00
- SKU:
- A2275-78A-ML650
- Purity:
- Purified by Protein A affinity chromatography from tissue culture supernatant.
- Storage Conditions:
- 4°C Do Not Freeze
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Synthetic peptide consisting of residues 1-17 of human amyloid beta protein. UniProt Accession: P05067
- Clone:
- 3H532 (DE2B4)
- Format:
- Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™650.
- Extra Details:
- MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Amyloid beta-protein/amyloid A4 or amyloid beta-peptide is derived from the amyloid beta-precursor protein. Beta amyloid is an extracellular filamentous protein deposit found in the brain. It is the major protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. In man, Alzheimer’s disease is the most common cause of senile dementia and is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type) and in the Guam Parkinson-Dementia complex. Applications: Suitable for use in FLISA, Immunohistochemisry and Immunoprecipitation. Not suitable for Western Blot. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): Requires protein digestion pre-treatment of paraffin sections using formic acid for 2-3 minutes. (Detects extracellular amyloid beta with senile plaques and vessel amyloid in Alzheimer's disease brain.) Optimal dilutions to be determined by the researcher. Recommended Secondary Antibody: I1904-65W: IgG, F(ab’)2 (HRP) Pab RbxMo I1904-66C: IgG, F(ab’)2, X-Adsorbed (HRP) Pab RbxMo Recommended Positive Control Tissue: Alzheimer's disease brain Recommended Negative Controls: I1904-78R: IgG1 Murine Negative Control Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Note: Applications are based on unconjugated antibody.
- Shipping Conditions:
- Blue Ice