Amyotrophic lateral sclerosis protein 2 (ALS2)

Size

£812.00

SKU:: A1362-86
Purity:: Purified by Protein G affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide (LKACYYQIQREKLN) corresponding to aa1644-1657 of human ALS2
Format:: Supplied as a liquid in PBS, pH 7.2.
Extra Details:: \Amyotrophic lateral sclerosis protein 2 (ALS2) or Alsin is a 184kD protein that contains three guanine-nucleotide exchange factor domains and may act as a GTPase regulator. ALS2 dysfunction affects endosome trafficking through a Rab5 small GTPases family-mediated mechanism. It is a causative gene for a juvenile autosomal recessive form of motor neuron diseases, including amyotrophic lateral sclerosis 2. This disorder is characterized by a progressive degeneration of the upper motor neurons of the motor cortex and the lower motor neurons of the brain stem and spinal cord. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.