A-769662 (6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile)

Size

£217.00

SKU:: A0001-68U
Molecular Weight:: 360.39
Purity:: ~99%
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 844499-71-4
Format:: Supplied as an off-white powder.
Extra Details:: A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an alpha beta gamma heterotrimer and plays an important role in regulating cellular and whole-body metabolism. A-769662 only activates AMPK heterotrimers containing the B1 subunit. A-769662 activates AMPK through the beta subunit carbohydrate-binding module and the gamma subunit but not the AMP-binding sites. Solubility: Soluble in DMSO at 33mg/ml; soluble in ethanol at 5mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Melting Point: 277-280ºC Elemental Analysis: Calculated 64.71% 3.58% 7.55% 8.64% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.