A0000-10
A20 Zinc Finger Protein
Size
£698.00
- SKU:
- A0000-10
- Purity:
- Purified by Protein G affinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Recombinant fusion protein corresponding to full length human A20 Zinc Finger Protein at the C-terminal portion of A20 (aa440-790).
- Clone:
- 4H16
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.05% BSA, 0.05% sodium azide.
- Extra Details:
- NF-kB (nuclear factor kB) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation. The zinc finger protein A20 is a tumor necrosis factor and interleukin 1 (IL-1)-inducible protein that negatively regulates NF-kB gene expression. A20 inhibits NF-kB dependent gene expression by interfering with a novel TNF-induced and RIP- or TRAF2-mediated pathway that is different from the NIK-IkB kinase pathway. A20 is expressed at low levels in most organs, the highest expression levels being in lymphoid tissues. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, Immunoprecipitation and Immunofluorescence. Other applications not tested. Recommended Dilutions: Flow Cytometry: Intracellular Western Blot: 2-4ug/ml Immunoprecipitation: 1-2ug/ml Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher. Positive Control: Jurkat cells, THP1 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice