Gamma-L-Glutamyl-L-glutamic acid (γ-Glu-Glu)

Size

£881.00

SKU:: 592469
Molecular Weight:: 276.24
Purity:: ≥98%
Supplier:: United States Biological
CAS Number:: 1116-22-9
Format:: White to off-white powder
Extra Details:: H-Glu(Glu-OH)-OH is a synthetic amino acid that is currently being investigated as a diagnostic agent for the detection of intracellular protein degradation by matrix metalloproteinase-9 (MMP-9). H-Glu(Glu-OH)-OH is taken up by cells in a concentration and time dependent manner, with an uptake rate of approximately 1.6 x 10^6 molecules per cell per hour. The uptake mechanism is not yet known, but has been hypothesized to be due to receptor binding. H-Glu(Glu-OH)-OH binds to cerebellar granule cells and alters mitochondrial metabolism, which may be related to its effects on the ubiquitin proteasome pathway. This compound also has diagnostic potential for atherosclerosis and glutamate transport disorders. Synonyms: γ-Glu-Glu; H-Glu(Glu-OH)-OH; ((S)-4-amino-4-carboxybutanoyl)-L-glutamic acid; (S)-2-((S)-4-Amino-4-carboxybutanamido)pentanedioic acid CAS No: 1116-22-9 Molecular Formula: C10H16N2O7 Molecular Weight: 276.24 Appearance: White to off-white powder Purity: ≥98% Melting Point: 179-182°C Specific Optical Rotation: 4 to 6° (20 °C, 589 nm) (c=1, 0,5 N HCl) Solubility: Water: 5% Storage and Stability: Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.