IGF1R, Teprotumumab Biosimilar (CD221)

Size

£512.00

SKU:: 592245
Purity:: Purified by Protein A/G affinity chromatography. ≥95%. Endotoxin: ≤1EU/mg (LAL)
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Human
Immunogen:: Recombinant protein corresponding to human IGF1R/CD221, expressed in CHO cells.
Format:: Supplied as a liquid in PBS, pH 7.4. No preservative added.
Extra Details:: Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor.8 Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 20163 and was approved by the FDA in January 2020 for the treatment of TED.7 Thyroid eye disease is a potentially debilitating complication of Graves' disease involving inflammation and tissue remodeling behind the eye, and previous treatment options typically involved multiple invasive surgeries-teprotumumab is the first drug ever approved for the treatment of TED and therefore represents a significant step forward in the treatment this disease. Applications: Suitable for use in Functional Assays. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice