591741
CD146, MUC18 (c3.19.1), Research Grade Biosimilar
Size
£749.00
- SKU:
- 591741
- Purity:
- ≥95%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Human
- Immunogen:
- Recombinant protein corresponding to human CD146/MUC18, expressed in CHO cells.
- Format:
- Supplied as a liquid in PBS, pH 7.5.
- Extra Details:
- c3.19.1 refers to a fully human IgG2 monoclonal antibody directed against the MUC18 antigen. The antibody was generated using XenoMouse® technology (Abgenix, Inc. Fremont, Calif.) and consists of human gamma 2 heavy and kappa light chains with a molecular weight of approximately 150kD. CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kD cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition. Applications: Suitable for use in ELISA and SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice