590604
LAG-3 Single Domain (LAG3)
Size
£691.00
- SKU:
- 590604
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Llama
- Immunogen:
- Recombinant protein corresponding to aa23-434 from the extracelluar domain of human LAG3.
- Clone:
- 2B11 (recomb)
- Format:
- Supplied as a liquid in PBS. No preservative added.
- Extra Details:
- The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy. Applications: Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry and Immunofluorescence. Other applications not tested. Recommended Dilutions: ELISA: 0.1ug/ml Immunofluorescence: 5ug/ml Immunohistochemistry (paraffin): 1ug/ml Flow Cytometry: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice