XBP-1

Size

£767.00

SKU:: 590541
Purity:: Purified by immunoaffinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Synthetic peptide corresponding to human XBP-1, spliced isoform XBP1(S) at C-terminal.
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER). XBP-1 mRNA is spliced by IRE1p under ER stress, resulting in a 371aa protein (XBP- 1s) which is translocated to the nucleus where it binds to the regulatory elements of downstream genes. XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones grp78 and grp94. Applications: Suitable for use in Western Blot, Immunocytochemistry and Flow Cytometry. Other applications not tested. Recommended Dilutions: Immunocytochemistry: 1:100 Flow Cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.