CD51

Size

£691.00

SKU:: 590097
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Human endothelial cells.
Clone:: L230
Format:: Supplied as a liquid in PBS, 0.05% sodium azide.
Extra Details:: CD51 (integrin αV subunit) associates with CD61 (integrin beta3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The alphaV/beta3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. alphaV/beta3 is also highly expressed in osteoclasts being important for bone resorption. Applications: Suitable for use in Functional Applications, Immunofluorescence, Flow Cytometry, ELISA, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Functional Applications: αV integrin blocking Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.