TWEAK

Size

£518.00

SKU:: 553911
Purity:: Purified by Protein G affinity chromatography from serum free tissue culture supernatant.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to aa97-249 of human TWEAK, expressed in E. coli.
Clone:: C06-3C8
Format:: Supplied as a liquid in PBS, 0.09% sodium azide.
Extra Details:: TWEAK is a 23kD type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily. While TWEAK is cell surface-associated, a smaller biologically active form can also be shed into the extracellular milieu. TWEAK, expressed primarily as a soluble cytokine by infiltrating leukocytes, mediates multiple activities through its receptor FGF-inducible molecule 14 (Fn14, TNFRSF12). It is a weak inducer of apoptosis in some cell types and is involved in the induction of inflammatory cytokines (Chicheportiche et al. 1997). This cytokine also promotes proliferation and migration of endothelial cells and acts as a regulator of angiogenesis. As a result of its pro-angiogenic effects, the role of this pathway in tumor biology has also been discussed (Michaelson & Burkly, 2009). Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice