GLRB

Size

£652.00

SKU:: 552937
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Purified recombinant protein fragment corresponding to aa:23-160 from human GLRB, expressed in E. coli.
Clone:: 3B8A8
Format:: Supplied as a liquid in PBS, 0.05% sodium azide.
Extra Details:: This gene encodes the beta subunit of the glycine receptor which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease also known as hereditary hyperekplexia or congenital stiff-person syndrome. This disease is characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. Applications: Suitable for use in ELISA, Flow Cytometry, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:10,000 Flow Cytometry: 1:200-1:400 Western Blot: 1:500-1:2000 Immunocytochemistry: 1:200-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.