544294
IDO1, Recombinant, Human, aa2-403, His-Tag
Size
£907.00
- SKU:
- 544294
- Molecular Weight:
- 46
- Purity:
- ≥90%
- Storage Conditions:
- -70°C
- Supplier:
- United States Biological
- Format:
- Supplied as a liquid in 40mM Tris, pH 8, 110mM sodium chloride, 2.2mM potassium chloride, 20% glycerol.
- Extra Details:
- IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders. Source: Recombinant protein corresponding to aa2-403 from human IDO1, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~46kD Assay Conditions: IDO1 activity was confirmed using the IDO1 Inhibitor Screening BioAssay™ Kit and following the protocol provided with the kit. Applications: Suitable for use in the study of enzyme kinetics, substrate specificity, and screening inhibitors. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Dry Ice