CD134 (OX40) (PE)

Size

£523.00

SKU:: 544192
Purity:: Purified by Protein A affinity chromatography from HEK293 supernatant.
Storage Conditions:: -70°C
Supplier:: United States Biological
Host:: Human
Immunogen:: Recombinant protein corresponding to human CD134 (OX40), expressed in HEK293 cells.
Clone:: 20E1
Format:: Supplied as a liquid in PBS, pH 7.4, 20% glycerol. Labeled with R-Phycoerythrin (PE).
Extra Details:: OX40, also known as CD134, is a co-stimulatory receptor, of the TNF (tumor necrosis factor) receptor family, expressed on the surface of T cells. Binding of OX40 to its ligand, OX40L (also known as CD252), potentiates T cell activation, differentiation, proliferation, survival, and T cell effector function. OX40L is present in NK cells, participating in their activation and cytotoxicity profile, and dendritic cells. OX40 can bind to members of the TRAF (TNFR associated factor) family of proteins, which can then regulate the NF-κF (nuclear factor kappa-light chain enhancer of activated B cells) signaling pathway. OX40 and OX40L can be found in cancer cells, such as AML (acute myeloid leukemia) and breast cancer cells. Studies have shown that OX40 agonists can increase anti-tumor immunity and improve tumor-free survival in pre-clinical studies. Alternatively, OX40 antagonists offer potential as therapeutics for inflammatory diseases. The development of new modulators of the OX40/OX40L activity are promising therapies for patients suffering from solid tumors or auto-immune disorders. Applications: Suitable for use in Flow Cytometry and Immunofluorescence Microscopy. Optimal dilutions to be determined by the researcher. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Shipping Conditions:: Dry Ice