NKp46/NCR1

Size

£448.00

SKU:: 532352
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to aa22-255 from human NKp46/NCR1 expressed in E. coli.
Clone:: n1D9
Format:: Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 10% glycerol.
Extra Details:: A natural cytotoxicity receptor (NCR), Nkp46, is a glycoprotein that has two extracellular Ig-like domains followed by a ~40 residue stalk resion, a type I transmembrane domain, and a short cytoplasmic tail. Nkp46 has been shown to represent a novel Nk cell-specific molecule involved in human Nk cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. Nkp46 has been implicated in Nk cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. Applications: Suitable for use in ELISA and FACS. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.