525839
NCSTN
Size
£665.00
- SKU:
- 525839
- Purity:
- Purified by immunoaffinity chromatography.
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to human NCSTN. Species sequence homology: Porcine (83%), Bovine (83%), Equine (83%), Sheep (83%), Rabbit (100%), Canine (83%), Xenopus (83%)
- Format:
- Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide, 50% glycerol.
- Extra Details:
- Nicastrin is a transmembrane glycoprotein serving as an essential component of the Gamma-secretase complex (1,2). Nicastrin is physically associated with presenilin and plays an important role in the stabilization and correct localization of presenilin to the membrane-bound Gamma-secretase complex (3). Nicastrin also serves as a docking site for Gamma-secretase substrates such as APP and Notch, directly binding to them and properly presenting them to Gamma-secretase to ensure the correct cleavage process (2,4). Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:2000, incubate membrane with diluted primary antibody in TBS, 5% milk, 0.1% Tween 20 at 4°C with gentle shaking, overnight. Immunohistochemistry: 1:50-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice