MUC1 (Mucin 1)

Size

£840.00

SKU:: 516751
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Rabbit
Immunogen:: Hydrogen fluoride deglycosylated milk mucin.
Clone:: SM3 (recomb)
Format:: Supplied as a liquid in PBS, 0.02% Proclin 300.
Extra Details:: Recombinant monoclonal antibody to MUC1. Manufactured using Recombinant Platform with variable regions (i.e. specificity) from the hybridoma SM3. Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. It is mapped to 1q22. Mucin 1 is a transmembrane mucin normally expressed on the apical borders of secretory epithelial cells. Overexpression of Mucin 1 is often associated with colon, breast, ovarian, lung and pancreatic cancers. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Mucin 1 stimulated ESR1-mediated transcription and contributed to estradiol-mediated growth and survival of breast cancer cells. This gene also can suppress pulmonary innate immunity, and its anti-inflammatory activity may play an important modulatory role during microbial infection. Applications: Suitable for use in ELISA, Immunohistochemistry and Flow Cytometry. Other applications not tested. Recommended Dilution: Immunohistochemistry: paraffin and frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice