Glucose-dependent Insulinotropic Receptor

Size

£840.00

SKU:: 516717
Purity:: Purified by Protein A affinity chromatography.
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Human GIPr.
Clone:: Gipg013 (recomb)
Format:: Supplied as a liquid in PBS, 0.02% Proclin 300.
Extra Details:: Recombinant monoclonal antibody to Glucose-dependent insulinotropic Receptor. Manufactured using Recombinant Platform with variable regions (i.e. specificity) from the scFv Gipg013. GIPr is a GPCR expressed on pancreatic beta-cells, where activation leads to the release of insulin. Endogeonous ligands for the receptor include oleylethanolamide and lysophosphatidylcholine. The antibody acts as a competitive antagonist. In rat islets, the antibody inhibits GIP-induced secretion of insulin by up to 81%. Applications: Suitable for use in Blocking, ELISA and Immunofluorescence. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.