FOLR2, Recombinant, Human, aa22-230, His-Tag

Size

£327.00

SKU:: 497039
Molecular Weight:: 25.1215
Purity:: ≥90% (SDS-PAGE). Endotoxin: ≤1EU/1ug (LAL)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.4, 10% glycerol
Extra Details:: FOLR2, also known as Folate receptor beta, is a member of the folate receptor (FLOR) family. Members of this gene family have a high affinity for folate and folic acid analogs at neutral pH. And they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. It was originally thought to exist only in placenta, but is also expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. FOLR2 is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. Recombinant protein corresponding to aa22-230 from FOLR2, fused to His-Tag at C-terminal, expressed in HEK293 cells. Molecular Weight: ~25.1kD Biological Activity: Measured by its binding ability in a functional ELISA with Folic Acid-BSA. The ED50 range ≤5ug/ml. Amino Acid Sequence: QDRTDLLNVC MDAKHHKTKP GPEDKLHDQC SPWKKNACCT ASTSQELHKD TSRLYNFNWD HCGKMEPACK RHFIQDTCLY ECSPNLGPWI QQVNQSWRKE RFLDVPLCKE DCQRWWEDCH TSHTCKSNWH RGWDWTSGVN KCPAGALCRT FESYFPTPAA LCEGLWSHSY KVSNYSRGSG RCIQMWFDSA QGNPNEEVAR FYAAAMHVN<H HHHHH> Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice