Rotavirus (VP6)

Size

£843.00

SKU:: 471338
Purity:: ≥95% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Recombinant protein corresponding to Rotavirus VP6.
Clone:: 18F573
Format:: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Extra Details:: The genus rotavirus belongs to the Reoviridae family of viruses. Rotaviruses are nonenveloped, double stranded RNA (dsRNA) viruses that are capable of infecting animals, birds and humans. In the mature virion, a complex triple-layered viral capsid surrounds a genome composed of eleven segments of dsRNA. These RNA segments code for 6 structural and 6 non-structural proteins (CDC). Rotavirus are classified according to the serological reactivity and genetic variability of the structural VP6 protein. Currently, eight species of rotavirus are recognized and are referred to as groups A-H. Group A rotaviruses are the most common cause of human disease, but group B and C rotaviruses have also been found to infect humans. Rotavirus is transmitted from person-to-person by the fecal oral route via contact with feces contaminated clothing, surfaces and infected individuals. Occasionally, the virus can also be transmitted via respiratory droplets produced by coughing or sneezing. Rotavirus infection is the most common cause of severe diarrhea in infants and young children worldwide. Symptoms of rotavirus infection include lethargy, fever, vomiting, abdominal pain, severe watery diarrhea and dehydration. Severe dehydration can often lead to hospitalization and in some cases death. Rotavirus infection in older children and adults may be mild or even asymptomatic. Effective vaccines are available which have helped to reduce severe diarrhea and childhood mortality, caused by rotavirus infection. However, rotavirus continues to have a major global impact on childhood morbidity and mortality, particularly in developing countries (WHO). Applications: Suitable for use in ELISA and Lateral Flow. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Matched Pairs: Self Pairs Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice