IL21, Recombinant, Human, aa30-162, His-Tag (IL21, CVID11, IL-21, Za11, Interleukin-21 isoform 1)

Size

£607.00

SKU:: 470240
Molecular Weight:: 16.91828
Purity:: ≥85% (SDS-PAGE)
Storage Conditions:: -20°C
Supplier:: United States Biological
Format:: Supplied as a liquid in PBS, pH 7.4, 20% glycerol.
Extra Details:: IL21, also known as interleukin-21 isoform 1, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumor responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the regulation of hematopoiesis and immune responses, and can influence lymphocyte development. It is produced by activated T cells, and it influences proliferation of T and B cells and cytolytic activity of natural killer cells. It may be a critical factor in the control of persistent viral infections. It has a potential predicating significance for survival time in patients in the development of sporadic CRC. It binds to the IL-21R and can activate Janus kinase JAK1, JAK3, STAT1, and STAT3 in EDgamma-16 cells. Recombinant protein corresponding to aa30-162 from human IL21, fused to His-Tag at C-terminal, expressed in Insect Cell. Molecular Weight: ~16.9kD (145aa) ~18-28kD (SDS-PAGE under reducing conditions) Amino Acid Sequence: ADPEFMQGQD RHMIRMRQLI DIVDQLKNYV NDLVPEFLPA PEDVETNCEW SAFSCFQKAQ LKSANTGNNE RIINVSIKKL KRKPPSTNAG RRQKHRLTCP SCDSYEKKPP KEFLERFKSL LQKMIHQHLS SRTHGSEDSH HHHHH Endotoxin: <1EU/1ug (LAL) Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Shipping Conditions:: Blue Ice