PTPRJ (CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1)

Size

£685.00

SKU:: 470129
Application:: WB
Purity:: Purified
Storage Conditions:: -20°C
Supplier:: United States Biological
Host:: Mouse
Immunogen:: Protein corresponding to aa1-1337 from full length human PTPRJ
Format:: Supplied as a liquid in PBS, pH 7.4.
Extra Details:: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGG TPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGT PQVETNTSEDGESSGANDSLRTPEQGSNGTDGASQK TPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKY VVKHKMENEKTITVVHQPWCNITGLRPATSYVFSITPGI GNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWS NGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGV QYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGS PTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTR YNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNIS ATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSE PRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPV PVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAG NSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS RTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASE YVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISP EVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAATLSW QNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATV TELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASM ASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGA WNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTV SCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSV KVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTY EDFKKGASDTYVTYLIRTEEKGRSQSLSEVLKYEIDVG NESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKG LIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGA LVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRV ENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAA ELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINAN YMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAI IMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEI VLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTG TFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTED QYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLA PVTTFGKTNGYIA Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Shipping Conditions:: Blue Ice