469968
DOK1 (MGC117395, MGC138860, P62DOK) (Not for Export EU)
Size
£685.00
- SKU:
- 469968
- Application:
- WB
- Purity:
- Serum
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- Host:
- Mouse
- Immunogen:
- Protein corresponding to aa1-481 from full length human DOK1.
- Format:
- Supplied as a liquid. No preservative added.
- Extra Details:
- Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. [provided by RefSeq] Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. AA Sequence: MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPH GVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVS VAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAA WVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLY SPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAER LTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEA GRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGK AGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPP ALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGV QRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEG LAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYN PATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGI KSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKS EGST Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Shipping Conditions:
- Blue Ice