468780
VU 6005649
Size
£453.00
- SKU:
- 468780
- Molecular Weight:
- 357.28
- Purity:
- ≥98%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 2137047-43-7
- Format:
- Yellow solid
- Extra Details:
- VU 6005649 is a positive allosteric modulator of mGlu7 and mGlu8 receptors (EC50 = 0.65uM and 2.6uM for mGlu7 and mGlu8, respectively). Displays >3.8 fold selectivity for mGlu7 and mGlu8 over other mGlu receptors (EC50 >10uM for mGlu1,2,3,4,5,6). Also NK1 receptor antagonist (Ki= 650 nM, IC50 = 3.4uM). Brain penetrant. Synonyms: 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine CAS No: 2137047-43-7 Molecular Formula: C₁₆H₁₂F₅N₃O Molecular Weight: 357.28 Solubility: 100mM in DMSO and to 50mM in ethanol Purity: ≥98% Appearance: Yellow solid 1H NMR and MS: Consistent with structure Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient