TPBM (Estrogen Receptor α (ERα) Inhibitor)

Size

£486.00

SKU:: 467756
Molecular Weight:: 316.38
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 6466-43-9
Extra Details:: TPBM is a potent inhibitor of estrogen receptor α via blocking ERα binding to consensus estrogen response element (cERE) DNA. Estrogen receptor α (ERα) plays an important role in several human cancers. Current ERα antagonists bind in the receptor ligand binding pocket and compete for binding with estrogenic ligands. TPBM instead inhibits ERα via binding to consensus estrogen response element (cERE) DNA. TPBM is not toxic to cells and does not effect estrogen-independent cell growth. TPBM does not act by chelating the zinc in ERs zinc fingers and differs from known ERα inhibitors. Synonyms: 8-Benzylsulfanylmethyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; 8-[(Benzylthio)methyl]theophylline CAS No: 6466-43-9 Molecular Formula: C15H16N4O2S Molecular Weight: 316.38 Purity(HPLC): ≥98% Appearance: White to off-white powder Solubility: DMSO: >5mg/ml Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.