466822
TAT-cyclo-CLLFVY
Size
£607.00
- SKU:
- 466822
- Molecular Weight:
- 2559.08
- Purity:
- ≥95%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 1446322-66-2
- Format:
- White, lyophilized solid
- Extra Details:
- TAT-cyclo-CLLFVY is a selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3uM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs. CAS No: 1446322-66-2 Molecular Formula: C₁₁₁H₁₈₈N₄₂O₂₄S₂ Molecular Weight: 2559.08 Sequence: CLLFVY CGRKKRRQRRRPPQ* (Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*) Purity: ≥95% Appearance: White, lyophilized solid Mass Spectrum: Consistent with structure Counter Ion: TFA Solubility: Soluble to 1mg/ml in water Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient