Rocaglamide (Roc-A)

Size

£576.00

SKU:: 464800
Molecular Weight:: 505.56
Purity:: ≥98%
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 84573-16-0
Format:: White to off-white powder
Extra Details:: Rocaglamide is derived from a Chinese medicinal plant Aglaia. Rocaglamide induces apoptosis in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients. Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia. Synonyms: Rocaglamide A; RocA; NSC 326408; (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide Molecular Formula: C₂₉H₃₁NO₇ Molecular Weight: 505.56 Appearance: White to off-white powder Purity: ≥98% Solubility: DMSO: 150mg/ml (sonicate) Storage and Stability: Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.