(R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole

Size

£453.00

SKU:: 463494
Molecular Weight:: 230.22
Purity:: ≥96%
Storage Conditions:: -20°C
Supplier:: United States Biological
CAS Number:: 94944-70-4
Format:: Off-white to light brown solid
Extra Details:: (R,S,R)-2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)-imidazole (THI) inhibits sphinogosine-1-phosphate (S1P) lyase for treatment of autoimmune disorders. Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists. 2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can affect lymphocyte migration and degradation. Synonyms: 1-[5-[(1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone; [1R-(1R*,2S*,3R*)]-1-[4-(1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl]-ethanone; 2-ATHBI CAS No: 94944-70-4 Molecular Formula: C₉H₁₄N₂O₅ Molecular Weight: 230.22 Appearance: Off-white to light brown solid Purity: ≥96% Melting Point: >200ºC (dec.) Solubility: Aqueous Acid (Slightly, Heated), DMSO (Slightly, Heated) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.