456094
Methylenebis(phosphonic Dichloride)
Size
£448.00
- SKU:
- 456094
- Molecular Weight:
- 249.78
- Purity:
- ≥95%
- Storage Conditions:
- -20°C
- Supplier:
- United States Biological
- CAS Number:
- 1499-29-2
- Format:
- White to off-white powder
- Extra Details:
- Methylenebis(phosphonic Dichloride) is used as a reagent in synthesis of several organic compounds including that of nucleoside 5'-methylenebis(phosphonate)s and bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis. Methylenebis(phosphonic dichloride) is a synthetic compound that is used in the synthesis of phosphonates. It has been shown to be toxic to mammalian cells, with an LD50 of 1.1mM/mL for K562 cells and 5.5mM/ml for fetal bovine cells. Methylenebis(phosphonic dichloride) has also been shown to have efficient cytotoxic activity against covid-19 pandemic virus (HIV). This compound has not been found to be mutagenic or carcinogenic in studies on mice, rats, or rabbits. It is thought that the cytotoxic effects are due to its ability to inhibit translation by binding to ribosomes and preventing the formation of polypeptides during protein synthesis. Methylenebis(phosphonic dichloride) can also be used in synthetic chemistry as a precursor for other compounds such as phosphinic acid and phosphonic acid. Synonyms: Phosphonic dichloride, P,P'-methylenebis- CAS No: 1499-29-2 Molecular Formula: CH2Cl4O2P2 Molecular Weight: 249.78 Purity: ≥95% Appearance: White to off-white powder 1H-NMR Spectrum: Conforms to reference Melting Point: 102-104°C (lit.) Solubility: Chloroform (Slightly), DMSO (Sparingly), Ethyl Acetate (Sparingly), Methanol (Slightly) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Moisture Sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
- Shipping Conditions:
- Ambient